Atorvastatin lipitor and simvastatin zocor are both statins that lower cholesterol levels in the bloodstream. Jan 19, 2016 penggunaan obat simvastatin ini boleh di konsumsi dengan melihat kadar kolesterol dalam darah, kondisi kesehatan dan seberapa beresikonya terkena serangan jantung dan stroke. Komaroff answers a question thats on a lot of peoples minds these days. Lipitor vs, zocor comparison will help us understand which drug among them is the best choice for you.
Reduce the risk of mi and stroke in adult patients with type 2 diabetes without chd, but with multiple risk factors. Materials and methods this study was a openlabel, randomized, parallelgroup, 8week comparative study evaluating the efficacy of oncedaily doses of atorvastatin 10 and 20mg compared with oncedaily doses of simvastatin 10 and 20mg. Compare atorvastatin vs pravastatin comprehensive analysis. Each dose doubling leads to an additional reduction of about 6 percentage points in ldlc e. And although they are the most effective drugs in lowering. Not every patient will experience all known sideeffects while on a treatment plan.
Both drugs work in the same way, helping to block a chemical necessary for making cholesterol. It reduces ldl and total cholesterol levels while increasing levels of hdl cholesterol. What are the differences between atorvastatin and simvastatin. Early results comparing atorvastatin to simvastatin demonstrated that atorvastatin appeared more potent and with fewer side effects. Difference between lipitor and crestor difference between. In turn, they help lower cholesterol, reduce risk for cardiac events and slow the progression of heart disease. This means that both atorvastatin and simvastatin are effective for high cholesterol and work similarly. Lipitor is utilized to cure high cholesterol levels, in order to reduce the chance of heart disease, heart attack, or additional heart issues in patient with type 2 diabetic issues, coronary heart conditions, or some other threat issues. Highdose atorvastatin vs usualdose simvastatin for secondary prevention after myocardial infarction. Lipitor atorvastatin is utilized in older people and young children who are a minimum of 1520 years old. Treatment with atorvastatin lipitor is not without some unwanted sideeffects but is frequently well tolerated. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers bureaus, stock ownership or options, expert testimony, royalties, donation of medical. Simvastatin is part of a group of drugs known as statins that reduce levels of ldl cholesterol in the blood while increasing levels.
In the secondary analysis, which compared the efficacy of atorvastatin 10 mg with that of simvastatin 10 mg, the mean decrease in ldl cholesterol was significantly greater p atorvastatin 10 mg than for simvastatin 10 mg 37. And it is not for women who are nursing, pregnant, or may become pregnant. Interventions patients were randomly assigned to receive a high dose of atorvastatin 80 mgd. Lipitor atorvastatin is a good option for people who have high cholesterol and diabetes. Aug 03, 2019 atorvastatin vs simvastatin which is better. Dec 28, 2011 atorvastatin significantly reduced the rate of coronary events either fatal coronary heart disease 46 events in the placebo group vs. Yes, it is safe to take turmeric in the diet if you are on atorvastatin. Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses stellar trial. Lipitor and zocor are statins used to treat high blood pressure and heart diseases that can lead to heart attack. Lipitor atorvastatin can lower the risk of heart attack, stroke, and death, particularly if you have diabetes, high blood pressure, obesity, or a history of smoking. How does simvastatin compare to lipitor atorvastatin. Comparison of the effects of atorvastatin versus simvastatin on.
This is the topmost selling drug in 2008 worldwide. Simvastatin zocor, generics 10 mg start with 5 mg in patients with severe renal insufficiency and monitor closely. Atorvastatin compared with simvastatinbased therapies in the. We compared atorvastatin with simvastatinbased therapies in a prospective observational study of 201 patients with severe hyperlipidaemia. Atorvastatin, sold under the brand name lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. Many sideeffects experienced are often mild and transient shortlived. In one trial atorvastatin 40 mg was used for downtitration if unable to tolerate 80 mg. The rationale for optimization employed a combination of insights from molecular modeling and hypothesisbased chemistry to define key structureactivity relationships. Because the risk for myopathy is doserelated, chinese patients should not receive simvastatin 80 mg coadministered with lipidmodifying doses of niacincontaining products.
Statin conversion chart % ldl reduction simvastatin zocor atorvastatin lipitor rosuvastatin crestor fluvastatin lescol lovastatin mevacor pravastatin pravachol ezetimibesimvastatin vytorin atorvastatin is effective at lowering cholesterol. For the prevention of cardiovascular disease, statins are a firstline treatment. Primary objective was to compare the effects of atorvastatin 40 mg vs 80 mg on ldlc in indian patients with atherosclerotic dyslipidemia. Dose conversion table for statins benefits english. Can i take turmeric curcumin with atorvastatin lipitor by fazila b.
Statins are often prescribed to help lower your cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself. Lipitor atorvastatin and zocor simvastatin are belong to the statin family of drugs that work to lower blood cholesterol, thereby treating a host of cardiovascular conditions, including. Reduce the risk of mi, stroke, revascularization procedures, and angina in adult patients without chd, but with multiple risk factors. Reduce the risk of nonfatal mi, fatal and nonfatal. Mar 16, 2009 the purpose of this study is to determine the efficacy of switching to a combination tablet ezetimibe simvastatin 10mg20mg versus rosuvastatin 10 mg versus doubling the statin dose in those patients who have cardiovascular disease and diabetes mellitus not adequately controlled on simvastatin 20 mg or atorvastatin 10 mg. The efficacy and safety of atorvastatin 10 mg versus simvastatin 20 mg and atorvastatin 80 mg versus simvastatin 80 mg was determined in a 6week, prospective, randomized, openlabel, blinded endpoint trial of dyslipidemic patients with and without. Pdf comparison of efficacy and safety of atorvastatin. Compare atorvastatin vs simvastatin headtohead with other drugs for uses, ratings, cost, side effects, interactions and more.
While zetia does lower cholesterol, there is to date no convincing evidence that it saves lives. Lipitor is used as an adjunct to diet for treatment of dyslipidaemia high cholesterol and triglyceride levels and coronary heart. The study is created by ehealthme based on reports of 512,011 people who take lipitor and cozaar, and is updated regularly. Statins are the only cholesterol drugs that have been clearly shown to reduce mortality that is, to save lives. Take lipitor each day at any time of day at about the same time each day. Your doctor should start you on a lowfat diet before giving you lipitor. Highdose atorvastatin after stroke or transient ischemic. There were no significant differences between the treatment groups for allcause mortality.
Atorvastatin compared with simvastatinbased therapies in. Atorvastatin was first made during 1985 by bruce roth and since then it has been manufactured by pfizer. Penggunaan atorvastatin ini tergantung pada kadar kolesterol dan. Why isnt rosuvastatin prescribed more frequently than. Grapefruit is one of the healthiest citrus fruits you can eat. Atorvastatin versus simvastatin tips and tricks from doctors. Why isnt rosuvastatin prescribed more frequently than atorvastatin as a lipid lowering agent in patients with typeii diabetes andor hypertension. Original paper comparison of the effects of simvastatin vs. Doctors give trusted answers on uses, effects, sideeffects, and cautions.
Lipitor atorvastatin and crestor rosuvastatin are hmgcoa reductase inhibitors statin drugs that lower cholesterol levels in the blood. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. The cause of the increased risk of myopathy is not known. The generic name of lipitor is atorvastatin calcium while the generic name of zocor is simvastatin. Lipitor atorvastatin and crestor rosuvastatin are hmgcoa reductase inhibitors statin drugs that lower cholesterol levels in the blood to reduce risk of heart attacks and stroke in patients with multiple risk factors. The side effects of atorvastatin 10 and 80 mg were similar and. Simvastatin is the drug of statins lass that goes under the brand name zocor and the atorvastatin is another drug from the class of statins and it undergoes by the name of the lipitor. Simvastatin zocor and atorvastatin lipitor are two types of statins that your doctor may prescribe for you. Statin dose intensity and equivalency chart statin intensity %ldlc reduction hmgcoa reductase inhibitor rosuvastatin atorvastatin pitavastatin simvastatin lovastatin pravastatin fluvastatin highintensity lowers ldlc. Atorvastatin 10 mg therapy was substituted for simvastatin 20 mg, 20 mg for 40 mg, 40 mg for simvastatin 40 mg plus resin, and 80 mg for simvastatin fibrateresin therapy.
If you miss a dose of lipitor, take it as soon as you remember. Statin treatment may be associated with adverse effects on. Atorvastatin 10mg, 20mg, 40mg, 80mg filmcoated tablets pharmacare 3. However, have you heard that you shouldnt mix grapefruit and certain medications. Weekly versus daily dosing of atorvastatin mdedge family. Lipitor is an hmgcoa reductase inhibitor indicated as an adjunct therapy to diet to. Atorvastatin and simvastatin are parts of a group of drugs called statins that revolutionized cholesterol management and heart disease prevention atorvastatin and simvastatin both target the same chemical in the body to reduce drastically the bloodstream levels of ldl lowdensity lipoprotein, or bad cholesterol, which lowers the risk it will clog up arteries, a central cause of. First, atorvastatin is a more potent medication than simvastatin, meaning taking a smaller dose of atorvastatin can be equal to taking a larger dose of simvastatin. Pdf atorvastatin compared with simvastatinbased therapies in the. Lipitor significantly reduced the rate of coronary events either fatal coronary heart disease 46 events in the placebo group vs. Compare lipitor vs simvastatin headtohead with other drugs for uses, ratings, cost, side effects, interactions and more.
Effects of different types of statins on lipid profile. Nevertheless, bruce roth and his bosses, roger newton and ronald cresswell, in 1985, convinced company executives to move the compound into expensive clinical trials. Highdose atorvastatin vs usualdose simvastatin for. Atorvastatin 10 mg therapy was substituted for simvastatin 20 mg, 20 mg for 40 mg, 40 mg for simvastatin 40 mg plus resin, and 80 mg for simvastatinfibrateresin therapy. Simvastatin and atorvastatin are effective statins for treating hypercholesterolemia. Identify all potential conflicts of interest that might be relevant to your comment. According to the comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with. Pdf highdose atorvastatin vs usualdose simvastatin for. Atorvastatin vs simvastatin uses, side effects, differences. Pdf we compared atorvastatin with simvastatinbased therapies in a.
Atorvastatin lipitor and simvastatin zocor belong to a class of medications known as statins, which are considered to be firstchoice medications for treating high cholesterol. Can i take turmeric curcumin with atorvastatin lipitor. Atorvastatin and simvastatin are medications that treat high blood cholesterol and triglycerides. Comparison of the efficacy of rosuvastatin versus atorvastatin, simvastatin, and pravastatin in achieving lipid goals.
Efficacy of atorvastatin compared with simvastatin in. Atorvastatin is a member of the drug class known as statins, used for lowering cholesterol and thereby reducing cardiovascular disease. We compare the side effects and drug effectiveness of lipitor and cozaar. These reduce the plasma concentration of simvastatin and atorvastatin and may reduce their effectiveness. Highlights of prescribing information warnings and precautions these highlights do not include all the information needed to use skeletal muscle effects e. Comparison of effects of simvastatin versus atorvastatin on. Note that lipitor is available as a generic, atorvastatin, and the price has dropped drastically from that shown in the report. Follow all directions given to you by your doctor and pharmacist carefully. This study suggests that atorvastatin reduces oxidative stress more effectively than simvastatin. Atorvastatin is also a substrate of pgp and oatp1b1 transporters and an inhibitor of pgp.
It belongs to a group of drugs known as hmgcoa reductase inhibitors statins. To study the effect of high dose atorvastatin 40 mg versus 80. Melihat lebih jauh obat kolesterol simvastatin vs lipitor. Anticoagulant effects of statins and their clinical implications. Bliss, rph, mba and the healthline editorial team side. Lipitor contains the molecule atorvastatin and is a member of the statin group of drugs. Lipitor and crestor are also used to reduce the risk of heart attacks, stroke, and arterial revascularization procedures in patients with multiple risk factors for heart disease. Aside from the obvious cost difference, which rx is better. We compared atorvastatin with simvastatin based therapies in a prospective observational study of 201 patients with severe hyperlipidaemia. August 3, 2019 august 3, 2019 by your health remedys staff. Hmgcoareductaseinhibitors pregnancycategoryx indications adjunctive management of primary hypercholesterolemia and mixed dyslipidemia. In general, both these medications lower bad cholesterol and triglycerides and increase good cholesterol in the process. In the february issue of the harvard health letter, editor in chief dr. The proportions of subjects who experienced cv or noncv death were similar for the lipitor 80 mg group and the simvastatin 2040 mg group.
Atorvastatin headtohead comparisons of medication uses, side effects. These drugs, part of a family called statins, are prescribed to treat a large number of cardiovascular disease, including to prevent heart failure. Several statinsatorvastatin, pravastatin, simvastatin. Lipitor atorvastatin calcium dose, indications, adverse. Lipitor atorvastatin improves your cholesterol levels and is a common first treatment for people with high cholesterol or heart disease. Comparison of the efficacy and tolerability of simvastatin and. Atorvastatin helps to lower your levels of cholesterol, but it does not cure your condition. Pdf comparison of efficacy and safety of atorvastatin and. Difference between zocor and lipitor difference between. You need to have liver tests, muscle problems including rhabdomyolysis, cognitive deficits with statins. Lovastatin pravastatin simvastatin % ldl reduction mevacor pravachol zocor lescol lipitor crestor vytorin 2532% 20 mg 20mg 10mg 40mg 39% 40mg 40mg 20mg 80mg 10mg 3745% 80mg 80mg 40mg 20mg 5mg 1010. Prescribed for high cholesterol, high cholesterol familial heterozygous. Its one of the strongest cholesterollowering statin medications. Effects on hdl cholesterol were not different between atorvastatin and the other reductase inhibitors except at the 20mg dose when atorvastatin produced greater elevations in hdl cholesterol than simvastatin.
Atorvastatin 6 figure 7 is a synthetic statin that contains an unusual pentasubstituted pyrrole ring in place of the hexahydronaphthalene found in the early statins. The bottom line is that i really do not want to take a statin at all but if i have to take one, i want to take what will work the best at lowering my ldl levels. Main outcome measure occurrence of a major coronary event, defined as coronary death, confirmed nonfatal acute mi. Crestor contains a molecule known as rosuvastatin and is also a member of the statin group of drugs. It is marketed under the brand name lipitor and is produced by pfizer. Why physicians favored lipitor over simvastatin clinical. Consult product labeling regarding use of this dose. Twentyfour consecutive patients of a single family physician who had achieved ncepii goal levels of lowdensity lipoprotein cholesterol ldlc on a daily atorvastatin dose of 10 mg for at least 6 months were invited to switch to 20 mg weekly. Backgroundstatins reduce the incidence of strokes among patients at increased risk for cardiovascular disease. Atorvastatin has the potential for significant drug interactions with cyp3a4 inhibitors, which may result in increased hmgcoa reductase inhibition and potential toxicity i. In my mind, there was little doubt of these facts long before the fda finally acted, which is why this physician, for one, prescribed lipitor for those patients who could obtain it and might benefit by switching to it from simvastatin.
Secondary objectives were to compare the effects of atorvastatin 40 mg vs 80 mg on hdlc and triglycerides and also comparing of side effects myopathy, hepatotoxicity and new onset diabetes mellitus of. Atorvastatin inhibits a ratedetermining enzyme located in hepatic tissue used in cholesterol synthesis, which lowers the amount of cholesterol produced. Fish oil epa dietary supplement or prescription vascepa no side effects except burping with dietary supplements, but less effective. Ezetimibesimvastatin mk0653a versus rosuvastatin versus. Buy this article and get unlimited access and a printable pdf. Apr 04, 2020 the differences between these two treatments are the differences in the medications themselves. However, there have been isolated case reports of rhabdomyolysis when they have been used in combination with simvastatin. Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia. However, when taking supplemental doses of turmeric or curcumin, it is better to maintain a gap of 34 hours between taking the two. Is generic atorvastatin as good as brandname lipitor.
Comparative efficacy study of atorvastatin vs simvastatin. Less is more when discussing ldl levels, but not when it comes to cpk levels and the risk of rhabdomyolysis. The differences between these two treatments are the differences in the medications themselves. Atorvastatin vs simvastatin side effects answers on healthtap. Atorvastatin belongs to a group of drugs called hmg coa reductase inhibitors. Route onset peak duration atorvastatin atorevastatin. Lipitor atorvastatin and zocor simvastatin are belong to the statin family of drugs that work to lower blood cholesterol, thereby treating a host of cardiovascular conditions, including congestive heart failure prevention. Untuk resep dokter biasanya menyarankan untuk meminum dengan dosis 540 mg per harinya. Statin conversion chart % ldl reduction simvastatin zocor atorvastatin lipitor rosuvastatin crestor fluvastatin lescol lovastatin mevacor pravastatin. Elisaf1 1 department of internal summary whats known medicine, medical school, background.
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